Magnesium Chloride → HCID 178488147, compound

HRID 2078443Notes

Reaction equation

HRID 2078443 reaction equation
[K].[CH3:2][O:3][C:4]1[CH:25]=[CH:24][C:7]2[NH:8][C:9]([S@:11]([CH2:13][C:14]3[C:19]([CH3:20])=[C:18]([O:21][CH3:22])[C:17]([CH3:23])=[CH:16][N:15]=3)=[O:12])=[N:10][C:6]=2[CH:5]=1.[Cl-].[Mg+2].[Cl-]>O>[CH3:23][C:17]1[CH:16]=[N:15][C:14]([CH2:13][S+:11]([O-:12])[C:9]2[NH:8][C:7]3[CH:24]=[CH:25][C:4]([O:3][CH3:2])=[CH:5][C:6]=3[N:10]=2)=[C:19]([CH3:20])[C:18]=1[O:21][CH3:22]

Participants

5

Reactant 3

HCID 5360315Magnesium ChlorideHCID 5462222PotassiumHCID 9568614Esomeprazole

Product 1

HCID 178488147HCID 178488147, compoundYield 76.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

Potassium salt of (S)-5-Methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl) methylsulfinyl]1-H-benzimidazole (Esomeprazole potassium) (5.2 gm) was dissolved in water (75 ml). To this solution, was added magnesium chloride solution (1.4 gm in 50 ml water), and then the contents were stirred for 1 hour at 25° C. The solid precipitated was filtered, washed with water and dried under vacuum for 12 hours at 40° C. to obtain 4.0 gm of esomeprazole magnessium dihydrate (enantiomeric excess: 99.7%).

Workup

  1. customThe solid precipitated
  2. filtrationwas filtered
  3. washwashed with water
  4. customdried under vacuum for 12 hours at 40° C.

Sources & evidence

ORD record
ord-68077952cd0643539127a8f9564700de
Source dataset
uspto-grants-2011_04
Patent number
US07928240B2

Reaction notes

Loading…