Isopropyl iodide → HCID 21466179, compound

Participants

Reaction Steps

To a mixture of 4,4′-oxydiphenol (3.680 g, 1.82 mmol) and 2-iodopropane (1.82 mL, 1.82 mmol) in ethanol (8.0 mL) at refluxing was added KOH (88%, 1.22 g, 1.91 mmol, 1.05 equivalents) in water (4.0 mL) over a period of 10 min. The resulting mixture was refluxed for 1 hour. Ethanol was removed. The residue was dissolved in ether, which was washed with brine (1×), dried over MgSO4 and concentrated. The residue was purified on a silica gel column eluting with ethyl acetate and hexane gradient to give the title product as a white solid (1.970 g, 44%)

Provenance & Evidence