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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2078474Generated: October 31, 2026

Phthalic Anhydride → 2-benzyl-3-hydroxy-2,3-dihydro-1H-isoindol-1-one

https://huagongshe.com/reaction/2078474

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhthalic AnhydrideHCID 6811—
ReactantBenzylamineHCID 7504—
ReactantHCID 4616003HCID 4616003—
Product2-benzyl-3-hydroxy-2,3-dihydro-1H-isoindol-1-oneHCID 3240743—

Reaction Steps

Compound 20 was prepared using the synthetic sequence in a manner analogous to the method described for the conversion of commercially available phthalic anhydride 1 to compound 12 using benzylamine instead of thiophene-2-methylamine in the first step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07928246B2
Source datasetuspto-grants-2011_04
ORD IDord-ada637847714408a97272c48a7a82cb9
Source noteuspto-grants-2011_04