HCID 10568063, compound → 2-(2-Benzyl-6-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yloxy)-N-pyridin-2-yl-acetamide

HRID 2078485Notes

Reaction equation

HRID 2078485 reaction equation
[CH2:1](OC(=O)COC1C2C(=CC=CC=2)C(=O)N1CC1C=CC=CC=1)C.[CH2:25]([N:32]1[C:40](=[O:41])[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:33]1[O:42][CH2:43][C:44]([NH:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][N:48]=1)=[O:45])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:25]([N:32]1[C:40](=[O:41])[C:39]2[C:34](=[CH:35][C:36]([CH3:1])=[CH:37][CH:38]=2)[CH:33]1[O:42][CH2:43][C:44]([NH:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][N:48]=1)=[O:45])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 10568063HCID 10568063, compoundHCID 166599022-(2-Benzyl-3-oxo-2,3-dihydro-1H-isoindol-1-yloxy)-N-pyridin-2-yl-acetamide

Product 1

HCID 576793412-(2-Benzyl-6-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yloxy)-N-pyridin-2-yl-acetamide

Procedure

Compound 61 was prepared using the synthetic sequence in a manner analogous to the method described for the conversion of compound 21 to compound 23 and illustrated in Scheme 2. NMR (300 MHz, CDCl3): δ 8.8 (br s, 1H), 8.45 (m, 1H), 8.1 (m, 1H), 7.75 (m, 2H), 7.4-7.2 (m, 7H), 7.05 (m, 1H), 5.9 (s, 1H), 5.0 (d, J=15 Hz, 1H), 4.4 (d, J=15 Hz, 1H), 3.65 (d, J=19 Hz, 1H), 3.5 (d, J=19 Hz, 1H), 2.4 (s, 3H). MS: m/z (MNa+) 410.

Sources & evidence

ORD record
ord-518fe4739e274c8787f913a4259cac27
Source dataset
uspto-grants-2011_04
Patent number
US07928246B2

Reaction notes

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