Cyclooctanone → 2-Oxonanone

Participants

Reaction Conditions

Reaction Steps

43.5 g (345 mmol) of cyclooctanone (compound of formula (VI) with n=6) (ACROS) are placed in solution in 430 ml of dichloroethane. 170 g (985 mmol) of meta-chloroperbenzoic acid are then added. The medium is heated to 80° C. for 48 hours. At room temperature, 400 ml of a Na2S2O5 and NaHCO3 saturated solution (1/1 v/v) are added. The medium is strongly stirred for 18 hours. The organic phase is separated and placed into the presence of KI and H2O for 6 hours. The organic phase is separated and washed with a Na2S2O3 saturated solution, with a NaCl saturated solution, and is then dried on MgSO4, filtered and concentrated in vacuo in order to obtain 36 g of crude product.

Provenance & Evidence