Hydrochloric Acid → 3-Fluorocatechol

Participants

Reaction Steps

To a 500 ml flask were added 119 g (0.5 mol) of 2-fluoro-6 -iodophenol and 200 ml of a 30% aqueous potassium hydroxide solution and they were reacted under vigorous stirring under a reflux temperature for 8 hours. After the termination of the reaction, the mixture was cooled to ordinary temperature and neutralized with hydrochloric acid to adjust pH between 2 and 3. After filtration, the filtrate was washed with water to obtain 49.9 g of a product [H]. The process yield was 78%.

Provenance & Evidence