HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminophenol → 4-(3-Aminophenoxy)pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminophenol | HCID 11568 | — |
| Reactant | 4-Chloropyridine-2-carboxamide | HCID 303543 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 4-(3-Aminophenoxy)pyridine-2-carboxamide | HCID 23137229 | — |
Reaction Steps
Entry 12: 4-Chloropyridine-2-carbonyl chloride HCl salt was reacted with ammonia according to Method A2, Step 3b to form 4-chloro-2-pyridinecarboxamide. 4-Chloro-2-pyridinecarboxamide was reacted with 3-aminophenol according to Method A2, Step 4 using DMAC in place of DMF to give 3-(2-carbamoyl-4-pyridyloxy)aniline. According to Method C2a, 2-methoxy-5-(trifluoromethyl)aniline was reacted with phosgene followed by 3-(2-carbamoyl-4-pyridyloxy)aniline afford the urea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928239B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-6ceb10e8536d474db8d61ed890ca209c |
| Source note | uspto-grants-2011_04 |