HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-5-(trifluoromethyl)aniline → 3-(4-Aminophenoxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-5-(trifluoromethyl)aniline | HCID 600637 | — |
| Reactant | Benzene, 2-isocyanato-1-methoxy-4-(trifluoromethyl)- | HCID 11983909 | — |
| Reactant | 3-(4-Aminophenoxy)benzoic acid | HCID 23009036 | — |
| Product | 3-(4-Aminophenoxy)benzoic acid | HCID 23009036 | — |
| Product | N-(5-(trifluoromethyl)-2-methoxyphenyl)-N'-(3-carboxyphenyl)urea | HCID 23614600 | — |
Reaction Steps
Entry 38: 4-(3-Carboxyphenoxy)aniline was synthesized according to Method A11. 5-(Trifluoromethyl)-2-methoxyaniline was converted into 5-(trifluoromethyl)-2-methoxyphenyl isocyanate according to Method B1. 4-(3-Carboxyphenoxy)aniline was reacted with 5-(trifluoromethyl)-2-methoxyphenyl isocyanate according to Method C1f to afford N-(5-(trifluoromethyl)-2-methoxyphenyl)-N′-(3-carboxyphenyl) urea, which was coupled with 5-amino-2-methoxypyridine according to Method D1c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928239B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-3e1f2011aa324957a5acaefcfe83658b |
| Source note | uspto-grants-2011_04 |