HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenol → 4-(2-(N-isopropylcarbamoyl)-4-pyridyloxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 4-chloropyridine-2-carbonyl Chloride | HCID 11095146 | — |
| Reactant | 4-Chloro-N-isopropyl-pyridine-2-carboxamide | HCID 22832083 | — |
| Product | 4-(2-(N-isopropylcarbamoyl)-4-pyridyloxy)aniline | HCID 23614560 | — |
Reaction Steps
Entry 100: 4-Chloropyridine-2-carbonyl chloride was reacted with isopropylamine according to Method A2, Step 3b. The resulting 4-chloro-N-isopropyl-2-pyridinecarboxamide was reacted with 4-aminophenol according to Method A2, Step 4 to give 4-(2-(N-isopropylcarbamoyl)-4-pyridyloxy)aniline. 4-Chloro-2-methoxy-5-(trifluoromethyl)aniline was synthesized according to Method A7. 4-Chloro-2-methoxy-5-(trifluoromethyl)aniline was converted into 4-chloro-2-methoxy-5-(trifluoromethyl)phenyl isocyanate according to Method B 1. According to Method C1a, 4-chloro-2-methoxy-5-(trifluoromethyl)phenyl isocyanate was reacted with 4-(2-(N-isopropylcarbamoyl)-4-pyridyloxy)aniline afford the urea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928239B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-f61c041078a047fe9c67e9eb02ab7aa0 |
| Source note | uspto-grants-2011_04 |