1,4-Dioxane hydrochloride → HCID 42639132, compound

HRID 2078633Notes

Reaction equation

HRID 2078633 reaction equation
[OH:1][C@H:2]([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)[CH2:3][N:4]([CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([NH:28][S:29]([CH3:32])(=[O:31])=[O:30])=[O:27])=[C:22]([O:33][CH:34]([CH3:36])[CH3:35])[CH:21]=2)=[CH:16][CH:15]=1)C(=O)OC(C)(C)C.O1CCOCC1.[ClH:49]>O1CCOCC1>[ClH:49].[OH:1][C@H:2]([C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)[CH2:3][NH:4][CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([NH:28][S:29]([CH3:32])(=[O:31])=[O:30])=[O:27])=[C:22]([O:33][CH:34]([CH3:36])[CH3:35])[CH:21]=2)=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67097085HCID 67097085, compound

Product 1

HCID 42639132HCID 42639132, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl [(2R)-2-hydroxy-2-phenylethyl][2-[3′-(isopropoxy)-4′-[[(methylsulfonyl)amino]carbonyl]-4-biphenylyl]ethyl]carbamate (65 mg) in 1,4-dioxane (2 ml) was added hydrochloric acid 1,4-dioxane solution (4N, 4 ml) at room temperature and the mixture was stirred at the same temperature for 2.5 hours. The mixture was evaporated under reduced pressure to give 4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-isopropoxy-N-(methylsulfonyl)-4-biphenylcarboxamide hydrochloride (38 mg).

Workup

  1. customThe mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-06566ca040e946d6b0562ee1f53f7151
Source dataset
uspto-grants-2011_04
Patent number
US07928264B2

Reaction notes

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