Hydrochloric Acid → HCID 67097907, compound

Participants

Reaction Steps

To a solution of tert-butyl [2-[4′-[[[4-[(tert-butoxycarbonyl)amino]butanoyl]amino]sulfonyl]-3′-(cyclohexyloxy)-4-biphenylyl]ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate (110 mg) in ethyl acetate (1 ml) was added hydrogen chloride in ethyl acetate (4N, 1 ml) at room temperature and the mixture was stirred at the same temperature for 6 hours. The mixture was filtered to collect the precipitate and the precipitate was washed with ethyl acetate/hexane (1:1). The precipitate was dried under reduced pressure to give 4-amino-N-[[3-(cyclohexyloxy)-4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]-amino]ethyl]-4-biphenylyl]sulfonyl]butanamide dihydrochloride (85 mg).

Provenance & Evidence