HCID 67097873, compound → HCID 67098335, compound

Participants

Reaction Steps

The mixture of 3-[[[[4′-[2-[(tert-butoxycarbonyl)-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-3-(cyclohexyloxy)-4-biphenylyl]carbonyl]amino]sulfonyl]-propyl acetate (269 mg) in hydrogen chloride methanol solution (10%, 2.7 ml) was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo and the residue was recrystallized from aqueous ethanol (50%) to give 4′-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-3-(cyclohexyloxy)-N-[(3-hydroxypropyl)sulfonyl]-4-biphenylcarboxamide hydrochloride (161 mg).

Provenance & Evidence