Formamide → HCID 67097705, compound

Participants

Reaction Conditions

Reaction Steps

Sodium methoxide (38.1 mg) was added to a solution of methyl 3-[[[[4′-[2-[(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-(cyclohexyloxy)-4-biphenylyl]carbonyl]amino]sulfonyl]propanoate (125 mg) in formamide (2.0 ml) at room temperature. The mixture was stirred for 1.5 hours at 60° C. The product was extracted with ethyl acetate. The combined extracts were washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by silica gel column chromatography to give tert-butyl [2-[4′-[[[(3-amino-3-oxopropyl)sulfonyl]amino]carbonyl]-3′-(cyclohexyloxy)-4-biphenylyl]ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate (22.0 mg).

Provenance & Evidence