HCID 67096903, compound → HCID 67098150, compound

Participants

Reaction Steps

A mixture of tert-butyl [(2R)-2-(3-chlorophenyl)-2-(tetrahydro-2H-pyran-2-yloxy)ethyl][2-[4-[1-isopropyl-3-[[(methylsulfonyl)amino]carbonyl]-1H-indol-6-yl]phenyl]-ethyl]carbamate (132 mg), 10% hydrogen chloride in methanol (2 ml) and 4N hydrogen chloride in 1,4-dioxane (2 ml) was stirred at room temperature for 12 hours. The resulting mixture was evaporated under reduced pressure. The residue was purified by reverse phase column chromatography followed by treatment of 1N hydrochloric acid to give 6-[4-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]phenyl]-1-isopropyl-N-(methylsulfonyl)-1H-indole-3-carboxamide hydrochloride (81 mg).

Provenance & Evidence