Formic Acid → HCID 57637359, compound

HRID 2078713Notes

Reaction equation

HRID 2078713 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:12]=[C:13]([NH2:18])[C:14]([NH2:17])=[CH:15][CH:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:19](O)=O>>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]3[N:17]=[CH:19][NH:18][C:13]=3[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 22897225HCID 22897225, compound2×

Product 1

HCID 57637359HCID 57637359, compound

Procedure

A mixture of 4-(3-piperidin-1-yl-propoxy)-benzene-1,2-diamine [2.2 g, Intermediate (39)] and formic acid (20 ml) at 100° C. was stirred for 3 hours and then cooled to room temperature and passed through a SCX column. The column was eluted with 7N ammonia in methanol to yield 6-(3-piperidin-1-yl-propoxy)-1H-benzoimidazole [3.45 g, Intermediate (40)] as a dark oil.; LC/MS: 260 (M+H).

Workup

  1. washThe column was eluted with 7N ammonia in methanol

Sources & evidence

ORD record
ord-be019707f4d94bc7a37ba2e69866b90f
Source dataset
uspto-grants-2011_04
Patent number
US07928231B2

Reaction notes

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