HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 2-Methyl-2-piperidin-1-ylpropanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Piperidine, hydrochloride (1:1) | HCID 2723721 | — |
| Reactant | 1-(Dimethylamino)cyclopentanecarbonitrile | HCID 10773049 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Methyl-2-piperidin-1-ylpropanenitrile | HCID 288882 | 77% |
Reaction Steps
The title compound (2.33 g, 77%) was prepared from piperidine hydrochloride (2.43 g, 20 mmol), acetone (1.16 g, 20 mmol) and potassium cyanide (1.30 g, 20 mmol) in water (10 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.46 (2H, m), 1.50 (6H, s), 1.63 (4H, m), 2.59 (4H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745642B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-512a6c3f8abe44da91d6031f77031de6 |
| Source note | uspto-grants-2010_06 |