反应详情

From Example 37, 4-(6,7-dihydropyrido[3,2-b]thieno[2,3-d]oxepin-9-yl)-(2-chlorophenyl)-2-amino-1H-imidazole 127 (27 mg, 0.062 mmol) was added to ethanol (2 mL, 30 mmol) containing 1 ml of 10% aqueous sulfuric acid. The reaction was microwaved on 300 watts at 100° C. for 15 minutes. The reaction mixture was mixed with 10 ml of 1 M aq Na2CO3 and extracted with ethyl acetate twice. The organic layer was washed with brine and dried over K2CO3. The solvent was evaporated to afford 128. (18 mg, 74%). MS (ESI+) 395.1

1. customThe reaction was microwaved on 300 watts at 100° C. for 15 minutes
2. extractionextracted with ethyl acetate twice
3. washThe organic layer was washed with brine
4. dry with materialdried over K2CO3
5. customThe solvent was evaporated