N,N-Dimethylpiperidin-4-amine → N-(2,4-dichlorophenyl)-9-(4-(dimethylamino)piperidine-1-carbonyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

Participants

Reaction Steps

2-[(2,4-Dichloro-phenyl)-methyl-carbamoyl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-9-carboxylic acid and 4-(dimethylamino)piperidine were reacted by General Procedure B to give 247. NMR: (CDCl3): 1.45-1.62 (2H, br m), 1.88-2.01 (2H, br, m), 2.39 (6H, s, Me), 2.50-2.61 (1H, br m), 2.82-3.10 (2H, br m), 3.07-3.09 (2H, m), 3.38 (3H, s, Me), 3.80-4.01 (1H, br m), 4.26-4.29 (2H, m), 4.58-4.79 (1H, br m), 6.85 (1H, s, Ar), 7.02 (1H, d, J 8.3, Ar), 7.25 (1H, dd, J 8.2 and 2.0, Ar), 7.28-7.32 (1H, m, Ar), 7.37-7.39 (1H, m, Ar), 7.55 (1H, s, Ar) and 7.60 (1H, s, Ar). MS: (ESI+) MH+=558.14

Provenance & Evidence