HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentanone → 1-(1-Pyrrolidinyl)cyclopentanecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentanone | HCID 8452 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-Methyl-2-(pyrrolidin-1-yl)propanenitrile | HCID 12570647 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(1-Pyrrolidinyl)cyclopentanecarbonitrile | HCID 586347 | 76% |
Reaction Steps
The title compound (2.50 g, 76%) was prepared from pyrrolidine (1.42 g, 20 mmol), cyclopentanone (1.68 g, 20 mmol) and potassium cyanide (1.30 g, 20 mmol) in water (10 ml) in a similar manner to that described in D4. 1H NMR (CDCl3) δ: 1.80-1.90 (10H, m), 2.15 (2H, m), 2.71 (4H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745642B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-234c1ac459684641914088447f710e5a |
| Source note | uspto-grants-2010_06 |