1-Methylpiperazine → N-(2,4-dichlorophenyl)-N-methyl-9-(4-methylpiperazine-1-carbonyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

Participants

Reaction Steps

2-[(2,4-dichloro-phenyl)-methyl-carbamoyl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-9-carboxylic acid and N-methylpiperazine were reacted by General Procedure B to give 359. NMR: (CDCl3): 2.40 (3H, s, Me), 2.49-2.58 (4H, br m), 3.06-3.09 (2H, m), 3.38 (3H, s, Me), 3.49-3.90 (4H, br m), 4.26-4.29 (2H, m), 6.83 (1H, s, Ar), 7.02 (1H, d, J 8.2, Ar), 7.25 (1H, dd, J 8.3 and 1.9, Ar), 7.31 (1H, d, J 8.4, Ar), 7.37 (1H, dd, J 8.4 and 2.2, Ar) and 7.55-7.57 (2H, m, Ar). MS: (ESI+) MH+=530.13

Provenance & Evidence