Ethanolamine → N2-(2,4-dichlorophenyl)-N9-(2-hydroxyethyl)-N2-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2,9-dicarboxamide

Participants

Reaction Steps

2-[(2,4-Dichloro-phenyl)-methyl-carbamoyl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-9-carboxylic acid and ethanolamine were reacted by General Procedure B to give 361. NMR: (CDCl3): 2.70-2.73 (1H, m, OH), 3.04-3.07 (2H, m), 3.38 (3H, s, Me), 3.66-3.70 (2H, m), 3.89-3.91 (2H, m), 4.26-4.29 (2H, m), 6.48-6.51 (1H, m, NH), 6.73 (1H, s, Ar), 7.02 (1H, d, J 8.4, Ar), 7.32 (1H, d, 8.4, Ar), 7.38 (1H, dd, J 8.4 and 2.2, Ar), 7.56-7.61 (2H, m, Ar) and 7.94 (1H, s, Ar). MS: (ESI+) MH+=532.08

Provenance & Evidence