HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 4,7-dibromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 7-Bromo-3,4-dihydro-1-benzoxepin-5(2H)-one | HCID 10681548 | — |
| Product | 4,7-dibromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one | HCID 57900458 | — |
Reaction Steps
Following the procedure for 449, Step 1, 7-bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one was reacted with bromine to afford the title compound as a white solid. 1H NMR (CDCl3): 7.86 (1H, d, J=2.6 Hz), 7.53 (1H, dd, J=8.7, 2.6 Hz), 6.96 (1H, d, J=8.7 Hz), 4.94 (1H, dd, J=7.6, 6.7 Hz), 4.43 (1H, ddd, J=12.7, 5.6, 4.7 Hz), 4.18 (1H, ddd, J=12.7, 9.7, 4.4 Hz), 2.97-2.87 (1H, m), 2.51 (1H, ddt, J=14.7, 7.6, 4.6 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928248B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-a2b8fcab6ca14b1db4b0d510678d79be |
| Source note | uspto-grants-2011_04 |