4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → HCID 53235289, compound

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Reaction Steps

Following the procedure for 484, Step 4, 9-bromo-2-(5-isopropyl-[1,2,4]triazol-1-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene was reacted with 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole to afford 489 as a white solid. LCMS (Method C): RT=10.17 min, [M+H]+=379. 1H NMR (DMSO-d6): 12.95 (1H, bs), 8.42 (1H, d, J=2.3 Hz), 8.18 (1H, s), 8.07 (1H, bs), 7.81 (1H, bs), 7.51 (1H, dd, J=8.3, 2.3 Hz), 7.06 (1H, d, J=8.3 Hz), 4.36 (2H, t, J=5.0 Hz), 4.12-4.04 (1H, m), 3.38 (2H, t, J=5.0 Hz), 1.47 (3H, s), 1.46 (3H, s).

Provenance & Evidence