HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2079049Generated: October 29, 2026
Lawesson's reagent → HCID 57900186, compound
https://huagongshe.com/reaction/2079049
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 8-bromo-N-(2-chlorophenyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide | HCID 57900159 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 57900186 | HCID 57900186 | 116% |
Reaction Steps
A solution of 8-bromo-N-(2-chlorophenyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide (10 g, 0.023 mol) in anhydrous 1,4-dioxane (400 mL) was treated with Lawesson's reagent (7.44 g, 0.018 mol) and heated at 85° C. for 4 h. The orange solution was cooled to room temperature and concentrated in vacuo. The crude product was washed with CH2Cl2 and then dried to give 8-bromo-N-(2-chlorophenyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carbothioamide as a yellow solid (9.41 g, yield 91%). ESI-MS: 449.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07928248B2 |
|---|
| Source dataset | uspto-grants-2011_04 |
|---|
| ORD ID | ord-881e504c2cff444d9f6299047259d106 |
|---|
| Source note | uspto-grants-2011_04 |
|---|
