Acetic Acid → tert-Butyl (5-bromo-4-cyclopropyl-1,3-thiazol-2-yl)carbamate

HRID 207911Notes

Reaction equation

HRID 207911 reaction equation
[Br:21][N:22]1[C:23](=[O:24])[CH2:25][CH2:26][C:27]1=[O:28].[C:17]([OH:18])(=[O:19])[CH3:20].[CH:1]1([c:4]2[n:5][c:6]([NH:9][C:10]([O:11][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:16])[s:7][cH:8]2)[CH2:2][CH2:3]1.[Na+:33].[O-:29][C:30]([OH:31])=[O:32]>>[CH:1]1([c:4]2[n:5][c:6]([NH:9][C:10]([O:11][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:16])[s:7][c:8]2[Br:21])[CH2:2][CH2:3]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 769Bicarbonate IonHCID 923Sodium ionHCID 67184N-bromobutanimideHCID 57634179HCID 57634179, compound

Product 1

HCID 45117858tert-Butyl (5-bromo-4-cyclopropyl-1,3-thiazol-2-yl)carbamate

Sources & evidence

ORD record
ord-6daa9a451e654ee2869e68ef5ecf508e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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