反应详情

After adding 5.59 g of N-bromosuccinimide to a solution of 5.11 g of 3-ethoxy-2-hydroxybenzaldehyde in 100 ml of acetonitrile, the mixture was stirred at room temperature for 3 hours. The reaction mixture was concentrated, water was added to the residue, and extraction was performed with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. The desiccating agent was filtered off and the filtrate was concentrated under reduced pressure. The residue was recrystallized using t-butyl methyl ether-heptane to give 5-bromo-3-ethoxy-2-hydroxybenzaldehyde (2.53 g).

1. concentrationThe reaction mixture was concentrated
2. additionwater was added to the residue, and extraction
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. filtrationThe desiccating agent was filtered off
5. concentrationthe filtrate was concentrated under reduced pressure
6. customThe residue was recrystallized