HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2079211Generated: October 30, 2026
Hydrochloric Acid → (2-Allyl-4-bromo-6-methoxyphenoxy)triisopropylsilane
https://huagongshe.com/reaction/2079211
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Triisopropylsilyl chloride | HCID 139400 | — |
| Reactant | 2-Allyl-4-bromo-6-methoxyphenol | HCID 57407756 | — |
| Reactant | 4-({[2-fluoro-3-(2-fluoroethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl}amino)benzamidine acetate | HCID 136366262 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (2-Allyl-4-bromo-6-methoxyphenoxy)triisopropylsilane | HCID 67097015 | — |
Reaction Steps
After dissolving 3g of 2-allyl-4-bromo-6-methoxy-phenol [CAS No. 352019-92-2] in 10 ml of DMF, 1.3 g of imidazole and 2g of chlorotriisopropylsilane were added and the mixture was stirred at 50° C. for 4 hours. Next, 1N hydrochloric acid was added to the reaction mixture and extraction was performed with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. The desiccating agent was filtered off, and the filtrate was concentrated under reduced pressure to give (2-allyl-4-bromo-6-methoxyphenoxy)triisopropylsilane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07928228B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-9d13c5536e954ff49aeaec60ebbdfc94 |
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| Source note | uspto-grants-2011_04 |
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