1-(4-Benzyl-piperazin-1-yl)-2-hydroxy-4-methyl-pentan-1-one → (R)-2-hydroxy-4-methyl-1-(piperazin-1-yl)pentan-1-one

HRID 2079271노트

반응식

HRID 2079271 반응식
C([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:21])[CH:15]([OH:20])[CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[OH:20][C@H:15]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:21]

참가 물질

4

반응물 1

HCID 670984871-(4-Benzyl-piperazin-1-yl)-2-hydroxy-4-methyl-pentan-1-one

생성물 1

HCID 59216548(R)-2-hydroxy-4-methyl-1-(piperazin-1-yl)pentan-1-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 1-(4-benzyl-piperazin-1-yl)-2-hydroxy-4-methyl-pentan-1-one (132 g) in methanol (1 L) was added Pd/C (20 g, 10% weight Pd on carbon). The reaction mixture was stirred at room temperature overnight under an atmosphere of hydrogen. The reaction mixture was filtered through Celite, and the solvent was removed in vacuo. (R)-2-Hydroxy-4-methyl-1-piperazin-1-yl-pentan-1-one was obtained as an oil (68 g, 74%).

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-34893bd2aede4bef8000e8637f733186
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07928107B2

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