Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → (3R)-oxolan-3-yl carbonochloridate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Phosgene | HCID 6371 | — |
| 반응물 | (-)-3-Hydroxytetrahydrofuran | HCID 641512 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (3R)-oxolan-3-yl carbonochloridate | HCID 58089797 | 85% |
반응 단계
A stirred solution of (R)-tetrahydrofuran-3-ol (7.9 g, 90 mmol) in anhydrous CH2Cl2 (50 mL) under an N2 atmosphere was cooled in an ice bath, and a 20% solution of phosgene in toluene (134 mL, 270 mmol) was slowly added. The reaction was allowed to warm to room temperature overnight, and the solvent was removed under vacuum to afford (R)-tetrahydrofuran-3-yl chloroformate (12.1 g, 85%) as a clear liquid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07928107B2 |
| 출처 데이터셋 | uspto-grants-2011_04 |
| ORD ID | ord-6f1d1aad33cd42699bfe53e812217d0d |
| 출처 메모 | uspto-grants-2011_04 |