HCID 58010950, compound → HCID 58010966, compound

HRID 2079330Notes

Reaction equation

HRID 2079330 reaction equation
[O:1]1[CH2:5][CH2:4][CH:3]([CH2:6][O:7][C:8]([N:10]2[CH2:15][CH2:14][N:13](CC3C=CC=CC=3)[CH2:12][CH2:11]2)=[O:9])[CH2:2]1.[H][H]>C(O)C.[Pd]>[O:1]1[CH2:5][CH2:4][CH:3]([CH2:6][O:7][C:8]([N:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)=[O:9])[CH2:2]1

Participants

5

Reactant 2

HCID 58010950HCID 58010950, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58010966HCID 58010966, compoundYield 103.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-Benzyl-piperazine-1-carboxylic acid tetrahydro-furan-3-ylmethyl ester (11.0 g) was dissolved in 100 ml ethanol. Palladium on carbon (10% Pd/C, 0.5 g) was added, and a hydrogen atmosphere was applied overnight at room temperature. The solution was filtered through Celite to remove the catalyst, and the Celite cake was rinsed with 50 ml ethanol. The combined filtrates were evaporated to dryness to yield piperazine-1-carboxylic acid tetrahydro-furan-3-ylmethyl ester (8.0 g) as a colorless oil.

Workup

  1. filtrationThe solution was filtered through Celite
  2. customto remove the catalyst
  3. washthe Celite cake was rinsed with 50 ml ethanol
  4. customThe combined filtrates were evaporated to dryness

Sources & evidence

ORD record
ord-e2e9478f78dd4fd1af257e8cb6a57d10
Source dataset
uspto-grants-2011_04
Patent number
US07928107B2

Reaction notes

Loading…