HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentanone → 1-(1-Azetidinyl)cyclopentanecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentanone | HCID 8452 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 1-(Dimethylamino)cyclopentanecarbonitrile | HCID 10773049 | — |
| Reactant | Azetidine hydrochloride | HCID 12308726 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(1-Azetidinyl)cyclopentanecarbonitrile | HCID 59347779 | 43% |
Reaction Steps
The title compound (1.29 g, 43%) was prepared from azetidine hydrochloride (1.85 g, 20 mmol), cyclopentanone (1.68 g, 20 mmol) and potassium cyanide (1.30 g, 20 mmol) in water (10 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.70-1.82 (6H, m), 1.86 (2H, m), 2.07 (2H, quin, J=7 Hz), 3.32 (4H, t, J=7 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745642B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-c1121d5546834bab92e2bff97a8f4126 |
| Source note | uspto-grants-2010_06 |