HuagongsheHuagongshe Chemistry Print Report · For research reference only
Mannitol → Zoledronic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Mannitol | HCID 6251 | — |
| Reactant | Zoledronic acid monohydrate | HCID 121586 | — |
| Solvent | Water | HCID 962 | — |
| Product | Zoledronic Acid | HCID 68740 | — |
Reaction Steps
533.1 mg of zoledronic acid monohydrate (equivalent to 500 mg of zoledronic acid) and 480.0 g of mannitol are added to 7520 g of water for injection and stirred until a clear solution with a total weight of 8000 g is obtained. Each 800 g of this solution (equivalent to 50 mg of zoledronic acid) are titrated with
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932241B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-7da73b7ec033446a9fb668c961cc3b4c |
| Source note | uspto-grants-2011_04 |