Glycinamide hydrochloride → HCID 11820468, compound

HRID 2079488Notes

Reaction equation

HRID 2079488 reaction equation
[CH:1]1([C:9]([OH:11])=O)[C:3]2([CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]2)[CH2:2]1.[NH2:12][CH2:13][C@@H:14]([OH:16])[CH3:15].Cl.NCC(N)=O>>[OH:16][C@@H:14]([CH3:15])[CH2:13][NH:12][C:9]([C@@H:1]1[C:3]2([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]2)[CH2:2]1)=[O:11]

Participants

4

Reactant 3

HCID 2723639Glycinamide hydrochlorideHCID 7311736(S)-(+)-1-Aminopropan-2-olHCID 10441897Spiro(2.5)octane-1-carboxylic Acid

Product 1

HCID 11820468HCID 11820468, compound

Procedure

The title compound was prepared as described in Example 3 substituting the product from Example 6 for the product from Example 1B and substituting (S)-1-amino-2-propanol, purchased from Aldrich, for 2-aminoacetamide hydrochloride. 1H NMR (400 MHz, CD3OD) δ 3.80 (m, 1H), 3.16 (m, 2H), 1.20-1.70 (m, 11H), 1.13 (d, 3H), 1.02 (dd, 1H), 0.69 (dd, 1H); MS (CI) m/z 212 (M+H)+.

Sources & evidence

ORD record
ord-66bc5575618549e48c3c599668cfc3e8
Source dataset
uspto-grants-2011_04
Patent number
US07932245B2

Reaction notes

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