m-Chloroperbenzoic acid → HCID 11817395, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (−5° C.) solution of 2-((3-hydroxy-4-methoxybenzyl)sulfanyl)acetic acid (2.9 g) in anhydrous DCM (15 mL) is added MCPBA (20 mmol, 50% concentration basis, Lancaster). The reaction mixture is stirred at −5° C. for 6 hours. The precipitated 3-chlorobenzoic acid is removed by filtration. The filtrate is washed with water, dried over magnesium sulfate and concentrated. After removal of the solvent, the product 2-((3-hydroxy-4-methoxy-benzyl)sulfinyl)acetic acid is purified either by crystallization or by silica gel chromatography.

Provenance & Evidence