HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-(4-Bromo-2-(trifluoromethyl)-phenoxy)propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Iodo-1-propanol | HCID 69390 | — |
| Reactant | o-Cresol, 4-bromo-alpha,alpha,alpha-trifluoro- | HCID 142784 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(4-Bromo-2-(trifluoromethyl)-phenoxy)propan-1-ol | HCID 57657591 | — |
Reaction Steps
3-Iodopropanol (11.23 g) was added to a mixture of 4-bromo-2-(trifluoromethyl)-phenol (15 g) and potassium carbonate (17.2 g) in acetonitrile (150 ml). The above mixture was refluxed for 4 hours then diluted with ethyl acetate (500 ml) and water (300 ml). Organic layer was separated, dried over magnesium sulphate, solvent removed under reduced pressure to give expected product clean enough for use at the next step (18.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932251B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-e5cc52859d744581ae4ae08e3cc3cf12 |
| Source note | uspto-grants-2011_04 |