HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoethane → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 67100725 | HCID 67100725 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 25204408 | HCID 25204408 | — |
Reaction Steps
1-Methyl-6-{4-[2-(piperidin-4-yl)-ethoxy]-3-(trifluoromethyl)-phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile hydrochloride (20 mg)7 ethyl iodide (10 mg) and potassium carbonate (20 mg) in acetonitrile (1 ml) was stirred at room temperature for 20 hours. After removal of solid by filtration, filtrate was purified by HPLC to give 6-{4-[2-(1-ethylpiperidin-4-yl)ethoxy]-3-(trifluoromethyl)phenyl}-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as TFA salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932251B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-64049940e6024cb8b62483ea86f45792 |
| Source note | uspto-grants-2011_04 |