Acryloyl chloride → HCID 67103285, compound

Participants

Reaction Steps

To a stirred solution of the oil isolated in Step E (313 mg, 1.4 mmol) in methylene chloride (10 mL) and saturated aqueous sodium bicarbonate solution (10 m) at 0° C. was added acryloyl chloride (115 μL, 1.4 mmol). The resulting mixture was stirred for 1 h and then was extracted with methylene chloride. The solution was concentrated, the resulting residue was dissolved in MeOH (3 mL) and aqueous LiOH solution (1N, 1 mL). The mixture was then stirred at room temperature for 30 minutes. The solution was acidified with 1N HCl and then extracted with methylene chloride. The solution was dried over sodium sulfate and concentrated to yield an oil.

Provenance & Evidence