Triethylamine → tert-butyl N-[1-(dimethylsulfamoyl)piperidin-4-yl]carbamate

Participants

Reaction Steps

To a solution of 412 mg (2.06 mmol) of tert-butyl 4-piperidinyl-carbamate in 20 mL of dichloromethane were added 430 μL (3.09 mmol) of triethylamine and 265 μL (2.47 mmol) of dimethylsulfamoyl chloride and the mixture was stirred for 2 hours at room temperature. Then, the mixture was treated with ethyl acetate and the organic layer was washed with water and saturated saline solution, and then, dried over with anhydrous sodium sulfate. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography (eluent:dichloromethane/methanol=40/1) to give 536 mg (85%) of the title compound.

Provenance & Evidence