2-Chloro-5-nitropyridine → 1-(5-nitropyridin-2-yl)piperidin-4-ol

Participants

Reaction Conditions

Reaction Steps

To a suspension of 11.0 g (6.3 mmol) of 2-chloro-5-nitropyridine in 20 mL of n-propanol was added 1.9 g (18.9 mmol) of 4-hydroxypiperidine, and the mixture was stirred for 1.5 hours at 100° C. After cooling the reaction mixture, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (eluent:dichloromethane/methanol=50/1) to give 1.37 g (97%) of the title compound.

Provenance & Evidence