HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 67103293, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 4-Piperidinol, 1-methyl- | HCID 66048 | — |
| Reactant | Di-tert-butyl diazene-1,2-dicarboxylate | HCID 6034084 | — |
| Reactant | HCID 67101622 | HCID 67101622 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67103293 | HCID 67103293 | 24.2% |
Reaction Steps
To a 0.3M solution of triphenylphosphine (1.5 eq) in THF was added di-tert-butylazodicarboxylate (1.5 eq). The mixture was stirred 15 minutes at ambient temperature. 4-Hydroxy-1-methylpiperidine (4.5 eq) was added. The mixture was stirred 15 minutes at ambient temperature. 3-(8-Hydroxyquinazolin-2-ylamino)benzenesulfonamide (1.0 eq) was added. The mixture was stirred an additional 1 hour. The crude mixture was concentrated, purified by RPHPLC, and lyophilized to give the desired product in 24.2% yield ES/MS m/z 414 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932262B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-528038f3722c451bb27c15f851e236ee |
| Source note | uspto-grants-2011_04 |