Sodium methanethiolate → HCID 136360484, compound

Participants

Reaction Conditions

Reaction Steps

To a 0.02M solution of 3-(7-Methoxyquinazolin-2-ylamino)benzenesulfonamide in NMP was added sodium thiomethoxide (5.0 eq) at ambient temperature. The reaction was stirred at 80° C. for 3 hours. The solid was collected by vacuum filtration and was partitioned between ethyl acetate and water. Saturated ammonium hydrochloride was added to aqueous phase until the PH=6. Aqueous phase was extracted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate and concentrated to give desired product in 85% yield. ES/MS m/z 317 (MH+).

Provenance & Evidence