Sulfanilamide → 4-[[8-Bromo-6-(trifluoromethyl)-2-quinazolinyl]amino]benzenesulfonamide

Participants

Reaction Conditions

Reaction Steps

To a 0.30 M solution of 8-bromo-2-chloro-6-(trifluoromethyl)quinazoline in 2-propanol was added sulfanilamide (1.0 eq). The reaction was stirred at 110° C. for 14 h. The hydrochloride was collected by vacuum filtration and then stirred in aqueous sodium bicarbonate. The solid was collected by vacuum filtration and rinsed with water. The light yellow solid was dried in a desiccator to give 343 mg of the desired product. ES/MS m/z 447, 449 (MH+).

Provenance & Evidence