HRID2079643

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2759392

1-(2-Methylpropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

C13H23BN2O2

HCID21835276

未命名化合物

结构：O=S(=O)(NCCCN1CCCC1)c1ccc(Nc2ncc3ccc(Br)cc3n2)cc1

HCID67101658

未命名化合物

PRODUCTS

生成物

结构：CC(C)Cn1cc(-c2ccc3cnc(Nc4ccc(S(=O)(=O)NCCCN5CCCC5)cc4)nc3c2)cn1

HCID59199245

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8071

未命名化合物

PROCEDURE

实验过程

Pd(dppf)2Cl2CH2Cl2 (0.05 eq) was added to a 0.05M mixture of 4-(7-bromoquinazolin-2-ylamino)-N-(3-(pyrrolidin-1-yl)propyl)benzenesulfonamide (eq), 1-isobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (3 eq), 2.0M potassium carbonate/water (2 eq) in DME. The mixture was microwaved at 120° C. for 10 min

WORKUP

后处理

customThe mixture was microwaved at 120° C. for 10 min

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2807c6050f9845cbb1810eaa26b07939
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07932262B2
来源说明: uspto-grants-2011_04

反应 SMILES

Br[C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[N:7][C:8]([NH:12][C:13]3[CH:18]=[CH:17][C:16]([S:19]([NH:22][CH2:23][CH2:24][CH2:25][N:26]4[CH2:30][CH2:29][CH2:28][CH2:27]4)(=[O:21])=[O:20])=[CH:15][CH:14]=3)=[N:9]2)=[CH:4][CH:3]=1.[CH2:31]([N:35]1[CH:39]=[C:38](B2OC(C)(C)C(C)(C)O2)[CH:37]=[N:36]1)[CH:32]([CH3:34])[CH3:33].C(=O)([O-])[O-].[K+].[K+].O>COCCOC>[CH2:31]([N:35]1[CH:39]=[C:38]([C:2]2[CH:11]=[C:10]3[C:5]([CH:6]=[N:7][C:8]([NH:12][C:13]4[CH:18]=[CH:17][C:16]([S:19]([NH:22][CH2:23][CH2:24][CH2:25][N:26]5[CH2:30][CH2:29][CH2:28][CH2:27]5)(=[O:20])=[O:21])=[CH:15][CH:14]=4)=[N:9]3)=[CH:4][CH:3]=2)[CH:37]=[N:36]1)[CH:32]([CH3:34])[CH3:33]