関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-amino-N-isopropylbenzamide | HCID 9812917 | — |
| 反応物 | 6-Bromo-2-chloro-7-methoxyquinazoline | HCID 59199276 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-(6-Bromo-7-methoxyquinazolin-2-ylamino)-N-isopropylbenzamide | HCID 67102252 | — |
反応手順
To a 0.25M suspension of 6-bromo-2-chloro-7-methoxyquinazoline in isopropanol was added 4-amino-N-isopropylbenzamide (1.0 eq). The reaction mixture was heated to 100° C. in an oil bath for 14 h. Reaction mixture was diluted with ethyl acetate and filtered to collect desired product. ES/MS m/z 415/417 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07932262B2 |
|---|
| 出典データセット | uspto-grants-2011_04 |
|---|
| ORD ID | ord-701180ebf96a4176abce7734efc0b38a |
|---|
| 出典メモ | uspto-grants-2011_04 |
|---|
