HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 59199291, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 67080801 | HCID 67080801 | — |
| Product | HCID 59199291 | HCID 59199291 | 50% |
Reaction Steps
To methyl 2-(4-sulfamoylphenylamino)quinazolin-7-carboxylic acid (1 eq) was added methylamine (2 eq) and DIEA (4 eq) and HBTU (2 eq) and the mixture was stirred at RT overnight. The coupling went to completion and the mixture was concentrated and partitioned between ethyl acetate and water. The organic layers were concentrated and purified on the prep HPLC to give N-methyl-2-(4-sulfamoylphenylamino)quinazoline-7-carboxamide in 50% yield. ES/MS m/z 358 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932262B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-20ac7a22ecbe4300a842cfc04a2bf5b2 |
| Source note | uspto-grants-2011_04 |