HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2079664Generated: October 27, 2026
4-(Morpholinosulfonyl)aniline → 7-methoxy-N-(4-(morpholinosulfonyl)phenyl)quinazolin-2-amine
https://huagongshe.com/reaction/2079664
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(Morpholinosulfonyl)aniline | HCID 210794 | — |
| Reactant | 2-Chloro-7-methoxyquinazoline | HCID 55251455 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 7-methoxy-N-(4-(morpholinosulfonyl)phenyl)quinazolin-2-amine | HCID 67102043 | 99% |
Reaction Steps
A mixture of 2-chloro-7-methoxyquinazoline (1 eq) and 4-(Morpholinosulfonyl) Aniline (1 eq) in 2-propanol was heated at 80° C. overnight. Product was precipitated in the reaction mixture. The precipitate was filtered, washed and dried under vacuum to provide 7-methoxy-N-(4-(morpholinosulfonyl)phenyl)quinazolin-2-amine as a yellow solid in 99% yield. ES/MS m/z 401.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07932262B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-2870def2946c4fbf870980bc780c82c2 |
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| Source note | uspto-grants-2011_04 |
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