Hydrochloric Acid → HCID 136029925, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-methoxy-N-(4-(morpholinosulfonyl)phenyl)quinazolin-2-amine (1 eq) and sodium thiomethoxide (4 eq) in NMP was heated at 80° C. for 4 h. Reaction mixture was diluted with water and acidified with 1N HCl. Compound was extracted with ethyl acetate. The organic layer was washed with satd. NaHCO3, brine and dried over sodium sulfate. Filtration, evaporation and drying under vacuum provide 2-(4-(morpholinosulfonyl)phenylamino) quinazolin-7-ol as a light yellow viscous liquid in 99% yield. ES/MS m/z 387.0 (MH+).

Provenance & Evidence