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HRID2079671

反应详情

EQUATION

反应方程式

HRID 2079671 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)OC(=O)N1CCC(Oc2ccc3cnc(Nc4ccc5[nH]c(=O)[nH]c5c4)nc3c2)CC1
HCID67102611

未命名化合物

PRODUCTS

生成物

1
结构：O=c1[nH]c2ccc(Nc3ncc4ccc(OC5CCNCC5)cc4n3)cc2[nH]1
HCID59199247

未命名化合物

收率 30%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl.O=C(O)C(F)(F)F
溶剂HCID21863450

未命名化合物

PROCEDURE

实验过程

A solution of crude tert-butyl 4-(2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-ylamino) quinazolin-7-yloxy)piperidine-1-carboxylate in 30% TFA/DCM was stirred at room temperature for 30 min. The solvent was evaporated and crude was purified by semi-prep HPLC to provide pure product in 30% yield ES/MS m/z 377.1 (MH+).

WORKUP

后处理

  1. customThe solvent was evaporated
  2. customcrude was purified by semi-prep HPLC
  3. customto provide pure product in 30% yield ES/MS m/z 377.1 (MH+)