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HRID2079676

反应详情

EQUATION

反应方程式

HRID 2079676 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)OC(=O)N1CCC(Oc2ccc(Br)c3cnc(Nc4ccc(N5CCOCC5)c(Cl)c4)nc23)CC1
HCID59199220

未命名化合物

PRODUCTS

生成物

1
结构：Clc1cc(Nc2ncc3c(Br)ccc(OC4CCNCC4)c3n2)ccc1N1CCOCC1
HCID67102237

未命名化合物

收率 50%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl.O=C(O)C(F)(F)F
溶剂HCID21863450

未命名化合物

PROCEDURE

实验过程

A solution of tert-butyl 4-(5-bromo-2-(3-chloro-4-morpholinophenylamino) quinazolin-8-yloxy)piperidine-1-carboxylate in 30% TFA/DCM was stirred at room temperature for 30 min. The solvent was evaporated and crude was purified by semi-prep HPLC to provide 5-bromo-N-(3-chloro-4-morpholinophenyl)-8-(piperidine-4-yloxy) quinazolin-2-amine in 50% yield. ES/MS m/z 518.0 (MH+).

WORKUP

后处理

  1. customThe solvent was evaporated
  2. customcrude was purified by semi-prep HPLC