Pivaloyl chloride → HCID 59199277, compound

Participants

Reaction Steps

To a solution of 2-methoxy-5-(trifluoromethyl) aniline (1 eq) in DCM at 0° C. was added TEA (1 eq) followed by dropwise addition of pivaloyl chloride (1 eq). The reaction mixture was warmed to room temperature and left stirred overnight. Diluted with DCM and washed with satd. sodium bicarbonate, water, brine and dried over sodium sulfate. Filtered, evaporated and dried under vacuum to provide pure product as an off white solid in 95% yield. ES/MS m/z 276.1 (MH+).

Provenance & Evidence